Cargando…

SNAI1-dependent upregulation of CD73 increases extracellular adenosine release to mediate immune suppression in TNBC

Triple-negative subtype of breast cancer (TNBC) is hallmarked by frequent disease relapse and shows highest mortality rate. Although PD-1/PD-L1 immune checkpoint blockades have recently shown promising clinical benefits, the overall response rate remains largely insufficient. Hence, alternative ther...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hasmim, Meriem, Xiao, Malina, Van Moer, Kris, Kumar, Akinchan, Oniga, Alexandra, Mittelbronn, Michel, Duhem, Caroline, Chammout, Anwar, Berchem, Guy, Thiery, Jean Paul, Volpert, Marianna, Hollier, Brett, Noman, Muhammad Zaeem, Janji, Bassam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501677/ https://www.ncbi.nlm.nih.gov/pubmed/36159844 http://dx.doi.org/10.3389/fimmu.2022.982821

Ejemplares similares

Epithelial to Mesenchymal Transition Regulates Surface PD-L1 via CMTM6 and CMTM7 Induction in Breast Cancer
por: Xiao, Malina, et al.
Publicado: (2021)

Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges
por: Noman, Muhammad Zaeem, et al.
Publicado: (2019)

Targeting Cytoprotective Autophagy to Enhance Anticancer Therapies
por: Xiao, Malina, et al.
Publicado: (2021)

A role for EMT in CD73 regulation in breast cancer
por: Hasmim, Meriem, et al.
Publicado: (2022)

Firing up the cold tumors by targeting Vps34
por: Janji, Bassam, et al.
Publicado: (2020)

Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy
por: Lequeux, Audrey, et al.
Publicado: (2021)

CMTM6 and CMTM7: New leads for PD‐L1 regulation in breast cancer cells undergoing EMT
por: Xiao, Malina, et al.
Publicado: (2022)

The β-carboline Harmine improves the therapeutic benefit of anti-PD1 in melanoma by increasing the MHC-I-dependent antigen presentation
por: Noman, Muhammad Zaeem, et al.
Publicado: (2022)

Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34
por: Janji, Bassam, et al.
Publicado: (2020)

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy
por: Noman, Muhammad Zaeem, et al.
Publicado: (2020)

The multifaceted role of autophagy in tumor evasion from immune surveillance
por: Janji, Bassam, et al.
Publicado: (2016)

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
por: Noman, Muhammad Zaeem, et al.
Publicado: (2014)

Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target
por: Noman, Muhammad Zaeem, et al.
Publicado: (2018)

Lighting Up the Fire in the Microenvironment of Cold Tumors: A Major Challenge to Improve Cancer Immunotherapy
por: Benoit, Alice, et al.
Publicado: (2023)

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner
por: Mgrditchian, Takouhie, et al.
Publicado: (2017)

Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress
por: Hasmim, Meriem, et al.
Publicado: (2015)

Hijacker of the Antitumor Immune Response: Autophagy Is Showing Its Worst Facet
por: Viry, Elodie, et al.
Publicado: (2016)

CXCL10 Is an Agonist of the CC Family Chemokine Scavenger Receptor ACKR2/D6
por: Chevigné, Andy, et al.
Publicado: (2021)

Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape
por: Chouaib, Salem, et al.
Publicado: (2012)

Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity
por: Janji, Bassam, et al.
Publicado: (2018)

Activation of NK cells and disruption of PD-L1/PD-1 axis: two different ways for lenalidomide to block myeloma progression
por: Giuliani, Massimo, et al.
Publicado: (2017)

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer
por: Berchem, Guy, et al.
Publicado: (2015)

SNAI1 recruits HDAC1 to suppress SNAI2 transcription during epithelial to mesenchymal transition
por: Sundararajan, Vignesh, et al.
Publicado: (2019)

High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia
por: Wierz, Marina, et al.
Publicado: (2018)

The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity
por: Baginska, Joanna, et al.
Publicado: (2013)

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment
por: Reynders, Nathan, et al.
Publicado: (2019)

The BET Protein Inhibitor JQ1 Decreases Hypoxia and Improves the Therapeutic Benefit of Anti-PD-1 in a High-Risk Neuroblastoma Mouse Model
por: Sauvage, Delphine, et al.
Publicado: (2022)

Deletion of Snai2 and Snai3 Results in Impaired Physical Development Compounded by Lymphocyte Deficiency
por: Pioli, Peter D., et al.
Publicado: (2013)

Epigenetic Activity of Peroxisome Proliferator-Activated Receptor Gamma Agonists Increases the Anticancer Effect of Histone Deacetylase Inhibitors on Multiple Myeloma Cells
por: Aouali, Nassera, et al.
Publicado: (2015)

Chemotherapy with ceramide in TNBC
por: Legembre, Patrick, et al.
Publicado: (2015)

GHRH-antagonists in TNBC
por: Engel, Jörg B.
Publicado: (2015)

Cripto-1 in TNBC
por: Castro, Nadia P, et al.
Publicado: (2015)

SNAI1 and SNAI2 Are Asymmetrically Expressed at the 2-Cell Stage and Become Segregated to the TE in the Mouse Blastocyst
por: Bell, Christine E., et al.
Publicado: (2009)

Absence of a Major Role for the Snai1 and Snai3 Genes in Regulating Skeletal Muscle Regeneration in Mice
por: Norton, Christine R., et al.
Publicado: (2013)

The actin filament cross-linker L-plastin confers resistance to TNF-α in MCF-7 breast cancer cells in a phosphorylation-dependent manner
por: Janji, Bassam, et al.
Publicado: (2010)

Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia
por: Moussay, Etienne, et al.
Publicado: (2010)

The Landscape of Targeted Therapies in TNBC
por: Vagia, Elena, et al.
Publicado: (2020)

CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis
por: Hoffmann, Céline, et al.
Publicado: (2016)

Neural Functions Play Different Roles in Triple Negative Breast Cancer (TNBC) and non-TNBC
por: Tan, Renbo, et al.
Publicado: (2020)

EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties
por: Deugnier, Marie-Ange, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_5ff6o9s9fi5ikqc1qros2660av