Scaffold Repurposing Reveals New Nanomolar Phosphodiesterase Type 5 (PDE5) Inhibitors Based on Pyridopyrazinone Scaffold: Investigation of In Vitro and In Silico Properties

Inhibition of PDE5 results in elevation of cGMP leading to vascular relaxation and reduction in the systemic blood pressure. Therefore, PDE5 inhibitors are used as antihypertensive and antianginal agents in addition to their major use as male erectile dysfunction treatments. Previously, we developed...

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Detalles Bibliográficos
Autores principales: Amin, Kamelia M., El-Badry, Ossama M., Abdel Rahman, Doaa E., Abdellattif, Magda H., Abourehab, Mohammed A. S., El-Maghrabey, Mahmoud H., Elsaid, Fahmy G., El Hamd, Mohamed A., Elkamhawy, Ahmed, Ammar, Usama M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501832/
https://www.ncbi.nlm.nih.gov/pubmed/36145702
http://dx.doi.org/10.3390/pharmaceutics14091954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501832/
https://www.ncbi.nlm.nih.gov/pubmed/36145702
http://dx.doi.org/10.3390/pharmaceutics14091954

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