Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment

Targeting the serine biosynthesis pathway enzymes has turned up as a novel strategy for anti-cancer therapeutics. 3- Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme that catalyzes the conversion of 3-Phosphoglyceric acid (3-PG) into 3-Phosphohydroxy pyruvate (3-PPyr) in the first...

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Detalles Bibliográficos
Autores principales: Sadiqa, Ayesha, Rasul, Azhar, Hassan, Mudassir, Sultana, Salma, Jabeen, Farhat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501931/
https://www.ncbi.nlm.nih.gov/pubmed/36144843
http://dx.doi.org/10.3390/molecules27186108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501931/
https://www.ncbi.nlm.nih.gov/pubmed/36144843
http://dx.doi.org/10.3390/molecules27186108

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