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Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment

Targeting the serine biosynthesis pathway enzymes has turned up as a novel strategy for anti-cancer therapeutics. 3- Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme that catalyzes the conversion of 3-Phosphoglyceric acid (3-PG) into 3-Phosphohydroxy pyruvate (3-PPyr) in the first...

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Detalles Bibliográficos
Autores principales:	Sadiqa, Ayesha, Rasul, Azhar, Hassan, Mudassir, Sultana, Salma, Jabeen, Farhat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501931/ https://www.ncbi.nlm.nih.gov/pubmed/36144843 http://dx.doi.org/10.3390/molecules27186108

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