Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations

Neisseria meningitidis protects itself from complement-mediated killing by binding complement factor H (FH). Previous studies associated susceptibility to meningococcal disease (MD) with variation in CFH, but the causal variants and underlying mechanism remained unknown. Here we attempted to define...

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Detalles Bibliográficos
Autores principales: Kumar, Vikrant, Pouw, Richard B., Autio, Matias I., Sagmeister, Manfred G., Phua, Zai Yang, Borghini, Lisa, Wright, Victoria J., Hoggart, Clive, Pan, Bangfen, Tan, Antson Kiat Yee, Binder, Alexander, Brouwer, Mieke C., Pinnock, Ellie, De Groot, Ronald, Hazelzet, Jan, Emonts, Marieke, Van Der Flier, Michiel, Reiter, Karl, Nöthen, Markus M., Hoffmann, Per, Schlapbach, Luregn J., Bellos, Evangelos, Anderson, Suzanne, Secka, Fatou, Martinón-Torres, Federico, Salas, Antonio, Fink, Colin, Carrol, Enitan D., Pollard, Andrew J., Coin, Lachlan J., Zenz, Werner, Wouters, Diana, Ang, Lay Teng, Hibberd, Martin L., Levin, Michael, Kuijpers, Taco W., Davila, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502058/
https://www.ncbi.nlm.nih.gov/pubmed/36007525
http://dx.doi.org/10.1016/j.ajhg.2022.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502058/
https://www.ncbi.nlm.nih.gov/pubmed/36007525
http://dx.doi.org/10.1016/j.ajhg.2022.08.001

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