Use of a Molecular Switch Probe to Activate or Inhibit GIRK1 Heteromers In Silico Reveals a Novel Gating Mechanism

G protein-gated inwardly rectifying K(+) (GIRK) channels form highly active heterotetramers in the body, such as in neurons (GIRK1/GIRK2 or GIRK1/2) and heart (GIRK1/GIRK4 or GIRK1/4). Based on three-dimensional atomic resolution structures for GIRK2 homotetramers, we built heterotetrameric GIRK1/2...

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Detalles Bibliográficos
Autores principales: Gazgalis, Dimitrios, Cantwell, Lucas, Xu, Yu, Thakur, Ganesh A., Cui, Meng, Guarnieri, Frank, Logothetis, Diomedes E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502415/
https://www.ncbi.nlm.nih.gov/pubmed/36142730
http://dx.doi.org/10.3390/ijms231810820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502415/
https://www.ncbi.nlm.nih.gov/pubmed/36142730
http://dx.doi.org/10.3390/ijms231810820

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