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Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors

Allosteric integrase (IN) inhibitors (ALLINIs), which are promising preclinical compounds that engage the lens epithelium-derived growth factor (LEDGF)/p75 binding site on IN, can inhibit different aspects of human immunodeficiency virus 1 (HIV-1) replication. During the late phase of replication, A...

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Detalles Bibliográficos
Autores principales:	Singh, Parmit Kumar, Li, Wen, Bedwell, Gregory J., Fadel, Hind J., Poeschla, Eric M., Engelman, Alan N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502684/ https://www.ncbi.nlm.nih.gov/pubmed/36146690 http://dx.doi.org/10.3390/v14091883

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