Zika Virus Inhibitors Based on a 1,3-Disubstituted 1H-Pyrazolo[3,4-d]pyrimidine-amine Scaffold

To search for Zika virus (ZIKV) antivirals, we have further explored previously reported 7H-pyrrolo[2,3-d]pyrimidines by examining an alternative substitution pattern of their central scaffold, leading to compound 5 with low micromolar antiviral activity. To circumvent the synthetic difficulties ass...

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Detalles Bibliográficos
Autores principales: Jung, Eunkyung, Soto-Acosta, Ruben, Geraghty, Robert J., Chen, Liqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502836/
https://www.ncbi.nlm.nih.gov/pubmed/36144841
http://dx.doi.org/10.3390/molecules27186109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502836/
https://www.ncbi.nlm.nih.gov/pubmed/36144841
http://dx.doi.org/10.3390/molecules27186109

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