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Zika Virus Inhibitors Based on a 1,3-Disubstituted 1H-Pyrazolo[3,4-d]pyrimidine-amine Scaffold

To search for Zika virus (ZIKV) antivirals, we have further explored previously reported 7H-pyrrolo[2,3-d]pyrimidines by examining an alternative substitution pattern of their central scaffold, leading to compound 5 with low micromolar antiviral activity. To circumvent the synthetic difficulties ass...

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Detalles Bibliográficos
Autores principales:	Jung, Eunkyung, Soto-Acosta, Ruben, Geraghty, Robert J., Chen, Liqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502836/ https://www.ncbi.nlm.nih.gov/pubmed/36144841 http://dx.doi.org/10.3390/molecules27186109

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