Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction

As a key structural protein, HIV capsid (CA) protein plays multiple roles in the HIV life cycle, and is considered a promising target for anti-HIV treatment. Based on the structural information of CA modulator PF-74 bound to HIV-1 CA hexamer, 18 novel phenylalanine derivatives were synthesized via t...

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Detalles Bibliográficos
Autores principales: Ji, Xiangkai, Li, Jing, Sharma, Prem Prakash, Jiang, Xiangyi, Rathi, Brijesh, Gao, Zhen, Hu, Lide, Kang, Dongwei, De Clercq, Erik, Cocklin, Simon, Liu, Chuanfeng, Pannecouque, Christophe, Dick, Alexej, Liu, Xinyong, Zhan, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502897/
https://www.ncbi.nlm.nih.gov/pubmed/36144727
http://dx.doi.org/10.3390/molecules27185995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502897/
https://www.ncbi.nlm.nih.gov/pubmed/36144727
http://dx.doi.org/10.3390/molecules27185995

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