Ligand-Free Signaling of G-Protein-Coupled Receptors: Relevance to μ Opioid Receptors in Analgesia and Addiction

Numerous G-protein-coupled receptors (GPCRs) display ligand-free basal signaling with potential physiological functions, a target in drug development. As an example, the μ opioid receptor (MOR) signals in ligand-free form (MOR-μ*), influencing opioid responses. In addition, agonists bind to MOR but...

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Detalles Bibliográficos
Autores principales: Sadee, Wolfgang, McKew, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503102/
https://www.ncbi.nlm.nih.gov/pubmed/36144565
http://dx.doi.org/10.3390/molecules27185826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503102/
https://www.ncbi.nlm.nih.gov/pubmed/36144565
http://dx.doi.org/10.3390/molecules27185826

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