Synthesis, Molecular Docking, In Vitro and In Vivo Studies of Novel Dimorpholinoquinazoline-Based Potential Inhibitors of PI3K/Akt/mTOR Pathway

A (series) range of potential dimorpholinoquinazoline-based inhibitors of the PI3K/Akt/mTOR cascade was synthesized. Several compounds exhibited cytotoxicity towards a panel of cancer cell lines in the low and sub-micromolar range. Compound 7c with the highest activity and moderate selectivity towar...

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Detalles Bibliográficos
Autores principales: Zapevalova, Maria V., Shchegravina, Ekaterina S., Fonareva, Irina P., Salnikova, Diana I., Sorokin, Danila V., Scherbakov, Alexander M., Maleev, Alexander A., Ignatov, Stanislav K., Grishin, Ivan D., Kuimov, Alexander N., Konovalova, Maryia V., Svirshchevskaya, Elena V., Fedorov, Alexey Yu.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503112/
https://www.ncbi.nlm.nih.gov/pubmed/36142768
http://dx.doi.org/10.3390/ijms231810854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503112/
https://www.ncbi.nlm.nih.gov/pubmed/36142768
http://dx.doi.org/10.3390/ijms231810854

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