Efficacy and Safety of Tacrolimus as Treatment for Bleeding Caused by Hereditary Hemorrhagic Telangiectasia: An Open-Label, Pilot Study

Haploinsufficiency for Endoglin (ENG) and activin A receptor type II-like I (ACVRL1/ALK1) lead to the formation of weak and abnormal vessels in hereditary hemorrhagic telangiectasia (HHT). These cause epistaxis (nosebleeds) and/or gastrointestinal blood loss. In vitro in cultured endothelial cells,...

Descripción completa

Detalles Bibliográficos
Autores principales: Hessels, Josefien, Kroon, Steven, Boerman, Sanne, Nelissen, Rik C., Grutters, Jan C., Snijder, Repke J., Lebrin, Franck, Post, Marco C., Mummery, Christine L., Mager, Johannes-Jurgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503120/
https://www.ncbi.nlm.nih.gov/pubmed/36142926
http://dx.doi.org/10.3390/jcm11185280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503120/
https://www.ncbi.nlm.nih.gov/pubmed/36142926
http://dx.doi.org/10.3390/jcm11185280

Ejemplares similares