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Efficacy and Safety of Tacrolimus as Treatment for Bleeding Caused by Hereditary Hemorrhagic Telangiectasia: An Open-Label, Pilot Study

Haploinsufficiency for Endoglin (ENG) and activin A receptor type II-like I (ACVRL1/ALK1) lead to the formation of weak and abnormal vessels in hereditary hemorrhagic telangiectasia (HHT). These cause epistaxis (nosebleeds) and/or gastrointestinal blood loss. In vitro in cultured endothelial cells,...

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Detalles Bibliográficos
Autores principales:	Hessels, Josefien, Kroon, Steven, Boerman, Sanne, Nelissen, Rik C., Grutters, Jan C., Snijder, Repke J., Lebrin, Franck, Post, Marco C., Mummery, Christine L., Mager, Johannes-Jurgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503120/ https://www.ncbi.nlm.nih.gov/pubmed/36142926 http://dx.doi.org/10.3390/jcm11185280

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