Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors

Two series of dimethoxy-halogenated chalcones (DM1–DM20) were synthesized and tested for their ability to inhibit monoamine oxidase (MAOs). Compound DM2 exhibited the most significant inhibition against MAO-B with an IC(50) value of 0.067 µM, followed by compound DM18 (IC(50) = 0.118 µM), with selec...

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Detalles Bibliográficos
Autores principales: Rehuman, Nisha Abdul, Oh, Jong Min, Abdelgawad, Mohamed A., Beshr, Eman A. M., Abourehab, Mohammed A. S., Gambacorta, Nicola, Nicolotti, Orazio, Jat, Rakesh Kumar, Kim, Hoon, Mathew, Bijo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503132/
https://www.ncbi.nlm.nih.gov/pubmed/36145373
http://dx.doi.org/10.3390/ph15091152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503132/
https://www.ncbi.nlm.nih.gov/pubmed/36145373
http://dx.doi.org/10.3390/ph15091152

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