Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation

BACKGROUND: Mitochondrial bioenergetics are sensitive to adenosine diphosphate (ADP) concentration. Reactive oxygen species (ROS) production and respiration [oxygen consumption rate (OCR)] are altered at physiological ADP concentrations (i.e. ADP insensitivity) in aged human muscle. Here, we investi...

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Detalles Bibliográficos
Autores principales: Pharaoh, Gavin, Brown, Jacob, Ranjit, Rojina, Ungvari, Zoltan, Van Remmen, Holly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503137/
https://www.ncbi.nlm.nih.gov/pubmed/36159599
http://dx.doi.org/10.1002/rco2.29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503137/
https://www.ncbi.nlm.nih.gov/pubmed/36159599
http://dx.doi.org/10.1002/rco2.29

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