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Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation
BACKGROUND: Mitochondrial bioenergetics are sensitive to adenosine diphosphate (ADP) concentration. Reactive oxygen species (ROS) production and respiration [oxygen consumption rate (OCR)] are altered at physiological ADP concentrations (i.e. ADP insensitivity) in aged human muscle. Here, we investi...
Autores principales: | Pharaoh, Gavin, Brown, Jacob, Ranjit, Rojina, Ungvari, Zoltan, Van Remmen, Holly |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503137/ https://www.ncbi.nlm.nih.gov/pubmed/36159599 http://dx.doi.org/10.1002/rco2.29 |
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