Deconstructing Markush: Improving the R&D Efficiency Using Library Selection in Early Drug Discovery

Most of the product patents claim a large number of compounds based on a Markush structure. However, the identification and optimization of new principal active ingredients is frequently driven by a simple Free Wilson approach, leading to a highly focused study only involving the chemical space near...

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Detalles Bibliográficos
Autores principales: Manen-Freixa, Leticia, Borrell, José I., Teixidó, Jordi, Estrada-Tejedor, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503783/
https://www.ncbi.nlm.nih.gov/pubmed/36145380
http://dx.doi.org/10.3390/ph15091159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503783/
https://www.ncbi.nlm.nih.gov/pubmed/36145380
http://dx.doi.org/10.3390/ph15091159

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