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Deconstructing Markush: Improving the R&D Efficiency Using Library Selection in Early Drug Discovery
Most of the product patents claim a large number of compounds based on a Markush structure. However, the identification and optimization of new principal active ingredients is frequently driven by a simple Free Wilson approach, leading to a highly focused study only involving the chemical space near...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503783/ https://www.ncbi.nlm.nih.gov/pubmed/36145380 http://dx.doi.org/10.3390/ph15091159 |