Molecular Insight into Mycobacterium tuberculosis Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants

We performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain Mycobacterium tuberculosis H37Rv. The...

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Detalles Bibliográficos
Autores principales: Mokrousov, Igor, Slavchev, Ivaylo, Solovieva, Natalia, Dogonadze, Marine, Vyazovaya, Anna, Valcheva, Violeta, Masharsky, Aleksey, Belopolskaya, Olesya, Dimitrov, Simeon, Zhuravlev, Viacheslav, Portugal, Isabel, Perdigão, João, Dobrikov, Georgi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504009/
https://www.ncbi.nlm.nih.gov/pubmed/36145357
http://dx.doi.org/10.3390/ph15091136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504009/
https://www.ncbi.nlm.nih.gov/pubmed/36145357
http://dx.doi.org/10.3390/ph15091136

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