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Molecular Insight into Mycobacterium tuberculosis Resistance to Nitrofuranyl Amides Gained through Metagenomics-like Analysis of Spontaneous Mutants
We performed synthesis of new nitrofuranyl amides and investigated their anti-TB activity and primary genetic response of mycobacteria through whole-genome sequencing (WGS) of spontaneous resistant mutants. The in vitro activity was assessed on reference strain Mycobacterium tuberculosis H37Rv. The...
Autores principales: | Mokrousov, Igor, Slavchev, Ivaylo, Solovieva, Natalia, Dogonadze, Marine, Vyazovaya, Anna, Valcheva, Violeta, Masharsky, Aleksey, Belopolskaya, Olesya, Dimitrov, Simeon, Zhuravlev, Viacheslav, Portugal, Isabel, Perdigão, João, Dobrikov, Georgi M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504009/ https://www.ncbi.nlm.nih.gov/pubmed/36145357 http://dx.doi.org/10.3390/ph15091136 |
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