Expression of Polyamine Oxidase in Fibroblasts Induces MMP-1 and Decreases the Integrity of Extracellular Matrix

Polyamine oxidase (PAOX) (N(1)-acetylpolyamine oxidase) is a major enzyme in the polyamine catabolism pathway that generates hydrogen peroxide. Hydrogen peroxide plays a crucial role in skin aging via extracellular matrix (ECM) degradation by increasing the matrix metalloproteinase-1 (MMP-1) levels....

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Detalles Bibliográficos
Autores principales: Jeong, Hae Dong, Kim, Jin Hyung, Kwon, Go Eun, Lee, Seung-Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504367/
https://www.ncbi.nlm.nih.gov/pubmed/36142401
http://dx.doi.org/10.3390/ijms231810487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504367/
https://www.ncbi.nlm.nih.gov/pubmed/36142401
http://dx.doi.org/10.3390/ijms231810487

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