Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives

Twenty-four analogues of benzimidazole-based thiazoles (1–24) were synthesized and assessed for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory potential. All analogues were found to exhibit good inhibitory potential against cholinesterase enzymes, having IC(5...

Descripción completa

Detalles Bibliográficos
Autores principales: Hussain, Rafaqat, Ullah, Hayat, Rahim, Fazal, Sarfraz, Maliha, Taha, Muhammad, Iqbal, Rashid, Rehman, Wajid, Khan, Shoaib, Shah, Syed Adnan Ali, Hyder, Sajjad, Alhomrani, Majid, Alamri, Abdulhakeem S., Abdulaziz, Osama, Abdelaziz, Mahmoud A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504419/
https://www.ncbi.nlm.nih.gov/pubmed/36144820
http://dx.doi.org/10.3390/molecules27186087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504419/
https://www.ncbi.nlm.nih.gov/pubmed/36144820
http://dx.doi.org/10.3390/molecules27186087

Ejemplares similares