Long-Lived Individuals Show a Lower Burden of Variants Predisposing to Age-Related Diseases and a Higher Polygenic Longevity Score

Longevity is a complex phenotype influenced by both environmental and genetic factors. The genetic contribution is estimated at about 25%. Despite extensive research efforts, only a few longevity genes have been validated across populations. Long-lived individuals (LLI) reach extreme ages with a rel...

Descripción completa

Detalles Bibliográficos
Autores principales: Torres, Guillermo G., Dose, Janina, Hasenbein, Tim P., Nygaard, Marianne, Krause-Kyora, Ben, Mengel-From, Jonas, Christensen, Kaare, Andersen-Ranberg, Karen, Kolbe, Daniel, Lieb, Wolfgang, Laudes, Matthias, Görg, Siegfried, Schreiber, Stefan, Franke, Andre, Caliebe, Amke, Kuhlenbäumer, Gregor, Nebel, Almut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504529/
https://www.ncbi.nlm.nih.gov/pubmed/36142858
http://dx.doi.org/10.3390/ijms231810949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504529/
https://www.ncbi.nlm.nih.gov/pubmed/36142858
http://dx.doi.org/10.3390/ijms231810949

Ejemplares similares