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Long-Lived Individuals Show a Lower Burden of Variants Predisposing to Age-Related Diseases and a Higher Polygenic Longevity Score

Longevity is a complex phenotype influenced by both environmental and genetic factors. The genetic contribution is estimated at about 25%. Despite extensive research efforts, only a few longevity genes have been validated across populations. Long-lived individuals (LLI) reach extreme ages with a rel...

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Detalles Bibliográficos
Autores principales:	Torres, Guillermo G., Dose, Janina, Hasenbein, Tim P., Nygaard, Marianne, Krause-Kyora, Ben, Mengel-From, Jonas, Christensen, Kaare, Andersen-Ranberg, Karen, Kolbe, Daniel, Lieb, Wolfgang, Laudes, Matthias, Görg, Siegfried, Schreiber, Stefan, Franke, Andre, Caliebe, Amke, Kuhlenbäumer, Gregor, Nebel, Almut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504529/ https://www.ncbi.nlm.nih.gov/pubmed/36142858 http://dx.doi.org/10.3390/ijms231810949

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