Thiopurine S-Methyltransferase Polymorphisms Predict Hepatotoxicity in Azathioprine-Treated Patients with Autoimmune Diseases

Thiopurine methyltransferase (TPMT) is the rate-limiting enzyme in Azathioprine (AZA) metabolization. Although studies have discussed the association between the TPMT polymorphisms and myelosuppression, the data about the relationship between TPMT genotypes and hepatoxicity in Asian patients remain...

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Detalles Bibliográficos
Autores principales: Sheu, Heh-Shiang, Chen, Yi-Ming, Liao, Yi-Ju, Wei, Chia-Yi, Chen, Jun-Peng, Lin, Hsueh-Ju, Hung, Wei-Ting, Huang, Wen-Nan, Chen, Yi-Hsing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504609/
https://www.ncbi.nlm.nih.gov/pubmed/36143183
http://dx.doi.org/10.3390/jpm12091399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504609/
https://www.ncbi.nlm.nih.gov/pubmed/36143183
http://dx.doi.org/10.3390/jpm12091399

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