Auxotrophic Lactobacillus Expressing Porcine Rotavirus VP4 Constructed Using CRISPR-Cas9D10A System Induces Effective Immunity in Mice

Porcine rotavirus (PoRV) mainly causes acute diarrhea in piglets under eight weeks of age and has potentially high morbidity and mortality rates. As vaccine carriers for oral immunization, lactic acid bacteria (LAB) are an ideal strategy for blocking PoRV infections. However, the difficulty in knock...

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Detalles Bibliográficos
Autores principales: Zhang, Hailin, Zhao, Haiyuan, Zhao, Yuliang, Sui, Ling, Li, Fengsai, Zhang, Huijun, Li, Jiaxuan, Jiang, Yanping, Cui, Wen, Ding, Guojie, Zhou, Han, Wang, Li, Qiao, Xinyuan, Tang, Lijie, Wang, Xiaona, Li, Yijing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504633/
https://www.ncbi.nlm.nih.gov/pubmed/36146587
http://dx.doi.org/10.3390/vaccines10091510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504633/
https://www.ncbi.nlm.nih.gov/pubmed/36146587
http://dx.doi.org/10.3390/vaccines10091510

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