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Auxotrophic Lactobacillus Expressing Porcine Rotavirus VP4 Constructed Using CRISPR-Cas9D10A System Induces Effective Immunity in Mice
Porcine rotavirus (PoRV) mainly causes acute diarrhea in piglets under eight weeks of age and has potentially high morbidity and mortality rates. As vaccine carriers for oral immunization, lactic acid bacteria (LAB) are an ideal strategy for blocking PoRV infections. However, the difficulty in knock...
Autores principales: | Zhang, Hailin, Zhao, Haiyuan, Zhao, Yuliang, Sui, Ling, Li, Fengsai, Zhang, Huijun, Li, Jiaxuan, Jiang, Yanping, Cui, Wen, Ding, Guojie, Zhou, Han, Wang, Li, Qiao, Xinyuan, Tang, Lijie, Wang, Xiaona, Li, Yijing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504633/ https://www.ncbi.nlm.nih.gov/pubmed/36146587 http://dx.doi.org/10.3390/vaccines10091510 |
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