Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles

ATP citrate lyase (ACLY) is a key enzyme in glucolipid metabolism and its aberrantly high expression is closely associated with various cancers, hyperlipemia and atherosclerotic cardiovascular diseases. Prospects of ACLY inhibitors as treatments of these diseases are excellent. To date, flavonoids h...

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Detalles Bibliográficos
Autores principales: Wang, Pan, Hou, Tao, Xu, Fangfang, Luo, Fengbin, Zhou, Han, Liu, Fan, Xie, Xiaomin, Liu, Yanfang, Wang, Jixia, Guo, Zhimou, Liang, Xinmiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504748/
https://www.ncbi.nlm.nih.gov/pubmed/36142671
http://dx.doi.org/10.3390/ijms231810747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504748/
https://www.ncbi.nlm.nih.gov/pubmed/36142671
http://dx.doi.org/10.3390/ijms231810747

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