Cargando…
Thymoquinone Inhibits JAK/STAT and PI3K/Akt/ mTOR Signaling Pathways in MV4-11 and K562 Myeloid Leukemia Cells
Constitutive activation of Janus tyrosine kinase-signal transducer and activator of transcription (JAK/STAT) and Phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathways plays a crucial role in the development of acute myeloid leukemia (AML) and chronic myel...
Autores principales: | Al-Rawashde, Futoon Abedrabbu, Al-wajeeh, Abdullah Saleh, Vishkaei, Mansoureh Nazari, Saad, Hanan Kamel M., Johan, Muhammad Farid, Taib, Wan Rohani Wan, Ismail, Imilia, Al-Jamal, Hamid Ali Nagi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504933/ https://www.ncbi.nlm.nih.gov/pubmed/36145344 http://dx.doi.org/10.3390/ph15091123 |
Ejemplares similares
-
Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells
por: Al-Rawashde, Futoon Abedrabbu, et al.
Publicado: (2021) -
Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling Pathway
por: Al-Rawashde, Futoon Abedrabbu, et al.
Publicado: (2023) -
Thymoquinone Inhibits Growth of Acute Myeloid Leukemia Cells through Reversal SHP-1 and SOCS-3 Hypermethylation: In Vitro and In Silico Evaluation
por: Al-Rawashde, Futoon Abedrabbu, et al.
Publicado: (2021) -
Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells
por: Almajali, Belal, et al.
Publicado: (2022) -
HBB Gene Mutations and Their Pathological Impacts on HbE/β-Thalassaemia in Kuala Terengganu, Malaysia
por: Saad, Hanan Kamel M., et al.
Publicado: (2023)