Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological Studies

Death-associated protein kinase 1 (DAPK1) is a serine/threonine protein kinase involved in diverse fundamental cellular processes such as apoptosis and autophagy. DAPK1 isoform plays an essential role as a tumor suppressor and inhibitor of metastasis. Consequently, DAPK1 became a promising target pr...

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Detalles Bibliográficos
Autores principales: Elkamhawy, Ahmed, Paik, Sora, Ali, Eslam M. H., Hassan, Ahmed H. E., Kang, So Jin, Lee, Kyeong, Roh, Eun Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504985/
https://www.ncbi.nlm.nih.gov/pubmed/36145271
http://dx.doi.org/10.3390/ph15091050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504985/
https://www.ncbi.nlm.nih.gov/pubmed/36145271
http://dx.doi.org/10.3390/ph15091050

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