Novel αO-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment

αO-conotoxin GeXIVA[1,2] was isolated in our laboratory from Conus generalis, a snail native to the South China Sea, and is a novel, nonaddictive, intramuscularly administered analgesic targeting the α9α10 nicotinic acetylcholine receptor (nAChR) with an IC(50) of 4.61 nM. However, its pharmacokinet...

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Detalles Bibliográficos
Autores principales: Zhu, Xiaoyu, Yuan, Mei, Wang, Huanbai, Zhangsun, Dongting, Yu, Gang, Che, Jinjing, Luo, Sulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505004/
https://www.ncbi.nlm.nih.gov/pubmed/36145535
http://dx.doi.org/10.3390/pharmaceutics14091789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505004/
https://www.ncbi.nlm.nih.gov/pubmed/36145535
http://dx.doi.org/10.3390/pharmaceutics14091789

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