Cargando…

Generation and Characterization of Drug-Resistant Influenza B Viruses Selected In Vitro with Baloxavir Acid

Baloxavir marboxil (BXM) is an antiviral drug that targets the endonuclease of the influenza polymerase acidic (PA) protein. Antiviral resistance, mainly mediated by the I38T PA substitution, readily occurs in both A(H1N1) and A(H3N2) viruses following a single dose of BXM. Influenza B resistance to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saim-Mamoun, Amel, Abed, Yacine, Carbonneau, Julie, Boivin, Guy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505253/ https://www.ncbi.nlm.nih.gov/pubmed/36145480 http://dx.doi.org/10.3390/pathogens11091048

Ejemplares similares

Viral Fitness of Baloxavir-Resistant Recombinant Influenza B/Victoria- and B/Yamagata-like Viruses Harboring the I38T PA Change, In Vitro, Ex Vivo and in Guinea Pigs
por: Saim-Mamoun, Amel, et al.
Publicado: (2023)

97. Competition Experiments for the Baloxavir-Resistant I38T Influenza A Mutant
por: Checkmahomed, Liva, et al.
Publicado: (2019)

In Vitro Combinations of Baloxavir Acid and Other Inhibitors against Seasonal Influenza A Viruses
por: Checkmahomed, Liva, et al.
Publicado: (2020)

Effects of Different Drug Combinations in Immunodeficient Mice Infected with an Influenza A/H3N2 Virus
por: Mhamdi, Zeineb, et al.
Publicado: (2020)

Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus
por: Baz, Mariana, et al.
Publicado: (2019)

Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada
por: Abed, Yacine, et al.
Publicado: (2019)

Impact of a large deletion in the neuraminidase protein identified in a laninamivir‐selected influenza A/Brisbane/10/2007 (H3N2) variant on viral fitness in vitro and in ferrets
por: Ann, Julie, et al.
Publicado: (2016)

Baloxavir Marboxil: An Original New Drug against Influenza
por: Dufrasne, François
Publicado: (2021)

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil
por: Omoto, Shinya, et al.
Publicado: (2018)

In Vitro Properties and Virulence of Contemporary Recombinant Influenza B Viruses Harboring Mutations of Cross-Resistance to Neuraminidase Inhibitors
por: Fage, Clément, et al.
Publicado: (2018)

Molecular Characterization of Viruses from Clinical Respiratory Samples Producing Unidentified Cytopathic Effects in Cell Culture
por: Abed, Yacine, et al.
Publicado: (2009)

Modeling mitigation of influenza epidemics by baloxavir
por: Du, Zhanwei, et al.
Publicado: (2020)

Susceptibility of Influenza A, B, C, and D Viruses to Baloxavir
por: Mishin, Vasiliy P., et al.
Publicado: (2019)

Detection of baloxavir resistant influenza A viruses using next generation sequencing and pyrosequencing methods
por: Patel, Mira C., et al.
Publicado: (2020)

Characterization of the In Vitro and In Vivo Efficacy of Baloxavir Marboxil against H5 Highly Pathogenic Avian Influenza Virus Infection
por: Taniguchi, Keiichi, et al.
Publicado: (2022)

A Review of Clinical Influenza A and B Infections With Reduced Susceptibility to Both Oseltamivir and Zanamivir
por: Abed, Yacine, et al.
Publicado: (2017)

Treatment of respiratory virus infections
por: Abed, Yacine, et al.
Publicado: (2006)

Role of Permissive Neuraminidase Mutations in Influenza A/Brisbane/59/2007-like (H1N1) Viruses
por: Abed, Yacine, et al.
Publicado: (2011)

Influenza A(H1N1)pdm09 Virus but Not Respiratory Syncytial Virus Interferes with SARS-CoV-2 Replication during Sequential Infections in Human Nasal Epithelial Cells
por: Fage, Clément, et al.
Publicado: (2022)

Susceptibility of Influenza Viruses to the Novel Cap-Dependent Endonuclease Inhibitor Baloxavir Marboxil
por: Takashita, Emi, et al.
Publicado: (2018)

The antiviral effects of baloxavir marboxil against influenza A virus infection in ferrets
por: Kitano, Mitsutaka, et al.
Publicado: (2020)

Efficacy of baloxavir marboxil on household transmission of influenza infection
por: Umemura, Takumi, et al.
Publicado: (2020)

Combination Therapy with Oseltamivir and Favipiravir Delays Mortality but Does Not Prevent Oseltamivir Resistance in Immunodeficient Mice Infected with Pandemic A(H1N1) Influenza Virus
por: Baz, Mariana, et al.
Publicado: (2018)

Impact of the H275Y and I223V Mutations in the Neuraminidase of the 2009 Pandemic Influenza Virus In Vitro and Evaluating Experimental Reproducibility
por: Paradis, Eric G., et al.
Publicado: (2015)

1350. Therapeutic Effects of Baloxavir Marboxil against Influenza A Virus Infection in Ferrets
por: Kitano, Mitsutaka, et al.
Publicado: (2018)

Reduced Prescription of Baloxavir After Suspected Prevalence of a Baloxavir-Resistant Influenza Virus Strain and the Emergence of SARS-CoV-2 in a Tertiary Hospital in Japan
por: Kamioka, Yasuhiro, et al.
Publicado: (2020)

Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002
por: Hamza, Hazem, et al.
Publicado: (2021)

648. Baloxavir Resistance: qPCR Detection of Antiviral Resistance Markers in Influenza A Virus
por: Tyler, Aaron J, et al.
Publicado: (2019)

Prophylactic Treatment with Baloxavir Protects Mice from Lethal Infection with Influenza A and B Viruses
por: Fukao, Keita, et al.
Publicado: (2023)

Design and Validation with Influenza A Virus of an Aerosol Transmission Chamber for Ferrets
por: Turgeon, Nathalie, et al.
Publicado: (2019)

Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus
por: Baba, Keiko, et al.
Publicado: (2020)

In vitro fitness of SARS-CoV-2 variants as assessed by competition experiments followed by ddRT-PCR and whole genome sequencing
por: Hénaut, Mathilde, et al.
Publicado: (2023)

Persistent Human Metapneumovirus Infection in Immunocompromised Child
por: Abed, Yacine, et al.
Publicado: (2008)

New Saffold Cardioviruses in 3 Children, Canada
por: Abed, Yacine, et al.
Publicado: (2008)

Human Parechovirus Infections in Canada
por: Abed, Yacine, et al.
Publicado: (2006)

Baloxavir Marboxil in Japanese Pediatric Patients With Influenza: Safety and Clinical and Virologic Outcomes
por: Hirotsu, Nobuo, et al.
Publicado: (2020)

The Comparison of the Efficacy of Baloxavir and Neuraminidase Inhibitors for Patients with Influenza A in Clinical Practice
por: Yoshii, Naoko, et al.
Publicado: (2020)

2645. Clinical Outcomes of Oseltamivir vs. Baloxavir in Patients Hospitalized with Influenza A
por: Shah, Sunish, et al.
Publicado: (2019)

Evaluation of Baloxavir Marboxil and Peramivir for the Treatment of High Pathogenicity Avian Influenza in Chickens
por: Twabela, Augustin, et al.
Publicado: (2020)

Pharmacokinetics, safety, and simulated efficacy of an influenza treatment, baloxavir marboxil, in Chinese individuals
por: Liu, Yanmei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r7hkgoa69rkhktehhj25ag809l