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Coordination Sites for Sodium and Potassium Ions in Nucleophilic Adeninate Contact ion-Pairs: A Molecular-Wide and Electron Density-Based (MOWED) Perspective
The adeninate anion (Ade(−)) is a useful nucleophile used in the synthesis of many prodrugs (including those for HIV AIDS treatment). It exists as a contact ion-pair (CIP) with Na(+) and K(+) (M(+)) but the site of coordination is not obvious from spectroscopic data. Herein, a molecular-wide and ele...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505275/ https://www.ncbi.nlm.nih.gov/pubmed/36144844 http://dx.doi.org/10.3390/molecules27186111 |