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Healthy-like CD4(+) Regulatory and CD4(+) Conventional T-Cell Receptor Repertoires Predict Protection from GVHD Following Donor Lymphocyte Infusion

Donor lymphocyte infusion (DLI) can (re-)induce durable remission in relapsing patients after allogeneic hematopoietic stem-cell transplantation (alloHSCT). However, DLI harbors the risk of increased non-relapse mortality due to the co-occurrence of graft-versus-host disease (GVHD). GVHD onset may b...

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Detalles Bibliográficos
Autores principales: Schneider, Jessica, Kuhlmann, Leonie, Xiao, Yankai, Raha, Solaiman, Bernhardt, Günter, Stadler, Michael, Thol, Felicitas, Heuser, Michael, Eder, Matthias, Ganser, Arnold, Ravens, Sarina, Förster, Reinhold, Prinz, Immo, Koenecke, Christian, Schultze-Florey, Christian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505302/
https://www.ncbi.nlm.nih.gov/pubmed/36142824
http://dx.doi.org/10.3390/ijms231810914