Chromosome silencing in vitro reveals trisomy 21 causes cell-autonomous deficits in angiogenesis and early dysregulation in Notch signaling

Despite the prevalence of Down syndrome (DS), little is known regarding the specific cell pathologies that underlie this multi-system disorder. To understand which cell types and pathways are more directly affected by trisomy 21 (T21), we used an inducible-XIST system to silence one chromosome 21 in...

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Detalles Bibliográficos
Autores principales: Moon, Jennifer E., Lawrence, Jeanne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505374/
https://www.ncbi.nlm.nih.gov/pubmed/35947952
http://dx.doi.org/10.1016/j.celrep.2022.111174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505374/
https://www.ncbi.nlm.nih.gov/pubmed/35947952
http://dx.doi.org/10.1016/j.celrep.2022.111174

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