Cargando…

Targeting of the Mitochondrial TET1 Protein by Pyrrolo[3,2-b]pyrrole Chelators

Targeting of epigenetic mechanisms, such as the hydroxymethylation of DNA, has been intensively studied, with respect to the treatment of many serious pathologies, including oncological disorders. Recent studies demonstrated that promising therapeutic strategies could potentially be based on the inh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Antonyová, Veronika, Tatar, Ameneh, Brogyányi, Tereza, Kejík, Zdeněk, Kaplánek, Robert, Vellieux, Fréderic, Abramenko, Nikita, Sinica, Alla, Hajduch, Jan, Novotný, Petr, Masters, Bettie Sue, Martásek, Pavel, Jakubek, Milan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505425/ https://www.ncbi.nlm.nih.gov/pubmed/36142763 http://dx.doi.org/10.3390/ijms231810850

Ejemplares similares

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design
por: Kejík, Zdeněk, et al.
Publicado: (2021)

Estrogen Receptor Modulators in Viral Infections Such as SARS−CoV−2: Therapeutic Consequences
por: Abramenko, Nikita, et al.
Publicado: (2021)

Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond
por: Kejík, Zdeněk, et al.
Publicado: (2021)

New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity
por: Talianová, Veronika, et al.
Publicado: (2022)

Access to pyrrolo-pyridines by gold-catalyzed hydroarylation of pyrroles tethered to terminal alkynes
por: Borsini, Elena, et al.
Publicado: (2011)

Going beyond the borders: pyrrolo[3,2-b]pyrroles with deep red emission
por: Tasior, Mariusz, et al.
Publicado: (2021)

Synthesis of unsymmetrically tetrasubstituted pyrroles and studies of AIEE in pyrrolo[1,2-a]pyrimidine derivatives
por: Li, Taian, et al.
Publicado: (2022)

Deciphering the unusual fluorescence in weakly coupled bis-nitro-pyrrolo[3,2-b]pyrroles
por: Poronik, Yevgen M., et al.
Publicado: (2020)

Method for the Large-Scale Synthesis of Multifunctional 1,4-Dihydro-pyrrolo[3,2-b]pyrroles
por: Tasior, Mariusz, et al.
Publicado: (2020)

Preparation and Physical Characterization of Pyrene and Pyrrolo[3,4‐c]pyrrole‐1,4‐dione‐Based Copolymers
por: Alqurashy, Bakhet A.
Publicado: (2019)

Reactivity of ethyl nitrosoacrylate toward pyrrole, indole and pyrrolo[3,2-c]carbazole: an experimental and theoretical study
por: Benzi, Alice, et al.
Publicado: (2023)

Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker
por: Pantier, Raphaël, et al.
Publicado: (2019)

Pentamethinium Salts Nanocomposite for Electrochemical Detection of Heparin
por: Shishkanova, Tatiana V., et al.
Publicado: (2021)

Pyrrole-Based Enaminones as Building Blocks for the Synthesis of Indolizines and Pyrrolo[1,2-a]pyrazines Showing Potent Antifungal Activity
por: Miranda-Sánchez, Diter, et al.
Publicado: (2023)

Contributing to Biochemistry and Optoelectronics: Pyrrolo[1′,2′:2,3]imidazo[1,5-a]indoles and Cyclohepta[4,5]pyrrolo[1,2-c]pyrrolo[1,2-a]imidazoles via [3+2] Annulation of Acylethynylcycloalka[b]pyrroles with Δ(1)-Pyrrolines
por: Oparina, Ludmila A., et al.
Publicado: (2023)

Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors
por: Belal, Amany, et al.
Publicado: (2022)

2,5-Dihexyl-3,6-diphenylpyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione
por: Sevinçek, Resul, et al.
Publicado: (2010)

Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3-b] Pyrrole Derivatives
por: Kamel, Moumen S., et al.
Publicado: (2022)

Hydrogen-Bonded Cyclic Dimers at Large Compression: The Case of 1H-pyrrolo[3,2-h]quinoline and 2-(2′-pyridyl)pyrrole
por: Kurzydłowski, Dominik, et al.
Publicado: (2021)

5-Bromo-1H-pyrrolo[2,3-b]pyridine
por: Štarha, Pavel, et al.
Publicado: (2013)

A New Synthetic Route to Polyhydrogenated Pyrrolo[3,4-b]pyrroles by the Domino Reaction of 3-Bromopyrrole-2,5-Diones with Aminocrotonic Acid Esters
por: Shikhaliev, Khidmet, et al.
Publicado: (2017)

Interactions of N-Mannich Bases of Pyrrolo[3,4-c]pyrrole with Artificial Models of Cell Membranes and Plasma Proteins, Evaluation of Anti-Inflammatory and Antioxidant Activity
por: Szczukowski, Łukasz, et al.
Publicado: (2023)

Three-dimensional organization of pyrrolo[3,2-b]pyrrole-based triazine framework using nanostructural spherical carbon: enhancing electrochemical performance of materials for supercapacitors
por: Hryniewicka, Agnieszka, et al.
Publicado: (2023)

Spectroscopic and Computational pH Study of Ni(II) and Pd(II) Pyrrole-Imine Chelates with Human Serum Albumin
por: Sookai, Sheldon, et al.
Publicado: (2023)

Synthesis of pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones: Rearrangement of pyrrolo[1,2-d][1,3,4]oxadiazines and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles
por: Son, Kkonnip, et al.
Publicado: (2016)

2,4-Diphenyl-6-trifluoromethyl-2,3-dihydro-1H,5H-pyrrolo[3,4-c]pyrrole-1,3-dione
por: Roberts, Sue A., et al.
Publicado: (2012)

Pyrrolo[3,2-b]pyrrole-1,4-dione (IsoDPP) End Capped with Napthalimide or Phthalimide: Novel Small Molecular Acceptors for Organic Solar Cells
por: Do, Thu Trang, et al.
Publicado: (2020)

The Adductomics of Isolevuglandins: Oxidation of IsoLG Pyrrole Intermediates Generates Pyrrole–Pyrrole Crosslinks and Lactams
por: Bi, Wenzhao, et al.
Publicado: (2019)

3-(4-Methoxyphenyl)-6-(phenylsulfonyl)perhydro-1,3-thiazolo[3′,4′:1,2]pyrrolo[4,5-c]pyrrole
por: Sundaramoorthy, S., et al.
Publicado: (2008)

Treatment of Substandard Rocket Fuel 1,1-Dimethylhydrazine via Its Methylene Derivative into Heterocycles Based on Pyrrolo-[3,4c]Quinolines, Cyclododeca[b]piran and Pyrrole
por: Ivanova, Elizaveta, et al.
Publicado: (2023)

Pyrrole-Pyridine and Pyrrole-Naphthyridine Hosts for Anion Recognition
por: García, M. Angeles, et al.
Publicado: (2015)

The Role of IL-6 in Cancer Cell Invasiveness and Metastasis—Overview and Therapeutic Opportunities
por: Rašková, Magdalena, et al.
Publicado: (2022)

Correction to “Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides”
por: Tokarenko, Anna, et al.
Publicado: (2019)

Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators
por: Said Fatahala, Samar, et al.
Publicado: (2017)

Synthesis of novel pyrroles and fused pyrroles as antifungal and antibacterial agents
por: Abd El-Hameed, Rania Helmy, et al.
Publicado: (2021)

Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19
por: Brábek, Jan, et al.
Publicado: (2020)

Copper–phenanthroline catalysts for regioselective synthesis of pyrrolo[3′,4′:3,4]pyrrolo[1,2-a]furoquinolines/phenanthrolines and of pyrrolo[1,2-a]phenanthrolines under mild conditions
por: Paira, Rupankar, et al.
Publicado: (2014)

William R. Brinkley (1936–2020)
por: Garrison, Howard H., et al.
Publicado: (2021)

Marine Pyrrole Alkaloids
por: Seipp, Kevin, et al.
Publicado: (2021)

Synthesis and reactivity of 2-thionoester pyrroles: a route to 2-formyl pyrroles
por: Kim, Min Joon, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_bdbuagse6qojaushueqd12ou4c