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Effective Preparation of [(18)F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor

(1) Background: [(18)F]Flumazenil 1 ([(18)F]FMZ) is an established positron emission tomography (PET) radiotracer for the imaging of the gamma-aminobutyric acid (GABA) receptor subtype, GABA(A) in the brain. The production of [(18)F]FMZ 1 for its clinical use has proven to be challenging, requiring...

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Detalles Bibliográficos
Autores principales: Haskali, Mohammad B., Roselt, Peter D., O’Brien, Terence J., Hutton, Craig A., Ali, Idrish, Vivash, Lucy, Jupp, Bianca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505495/
https://www.ncbi.nlm.nih.gov/pubmed/36144667
http://dx.doi.org/10.3390/molecules27185931