Cargando…

Effective Preparation of [(18)F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor

(1) Background: [(18)F]Flumazenil 1 ([(18)F]FMZ) is an established positron emission tomography (PET) radiotracer for the imaging of the gamma-aminobutyric acid (GABA) receptor subtype, GABA(A) in the brain. The production of [(18)F]FMZ 1 for its clinical use has proven to be challenging, requiring...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haskali, Mohammad B., Roselt, Peter D., O’Brien, Terence J., Hutton, Craig A., Ali, Idrish, Vivash, Lucy, Jupp, Bianca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505495/ https://www.ncbi.nlm.nih.gov/pubmed/36144667 http://dx.doi.org/10.3390/molecules27185931

Ejemplares similares

4-Nitrophenyl activated esters are superior synthons for indirect radiofluorination of biomolecules
por: Haskali, Mohammad B., et al.
Publicado: (2020)

In Vivo Measurement of Hippocampal GABA(A)/cBZR Density with [(18)F]-Flumazenil PET for the Study of Disease Progression in an Animal Model of Temporal Lobe Epilepsy
por: Vivash, Lucy, et al.
Publicado: (2014)

Copper-Mediated Radiofluorination of Arylstannanes with [(18)F]KF
por: Makaravage, Katarina J., et al.
Publicado: (2016)

Strained Ammonium Precursors for Radiofluorinations
por: Reissig, Falco, et al.
Publicado: (2022)

Development of Customized [(18)F]Fluoride Elution Techniques for the Enhancement of Copper-Mediated Late-Stage Radiofluorination
por: Mossine, Andrew V., et al.
Publicado: (2017)

Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin
por: S. Clemente, Gonçalo, et al.
Publicado: (2019)

Photocatalytic stannylation of white phosphorus
por: Till, Marion, et al.
Publicado: (2022)

Nucleophilic Synthesis of 6-l-[(18)F]FDOPA. Is Copper-Mediated Radiofluorination the Answer?
por: Krasikova, Raisa N.
Publicado: (2020)

A Practical Method for the Preparation of (18)F-Labeled Aromatic Amino Acids from Nucleophilic [(18)F]Fluoride and Stannyl Precursors for Electrophilic Radiohalogenation
por: Zarrad, Fadi, et al.
Publicado: (2017)

Radiofluorination using aluminum-fluoride (Al(18)F)
por: McBride, William J, et al.
Publicado: (2013)

Multi-patient dose synthesis of [(18)F]Flumazenil via a copper-mediated (18)F-fluorination
por: Gendron, Thibault, et al.
Publicado: (2022)

Stereoselective C–O silylation and stannylation of alkenyl acetates
por: Hu, Ying, et al.
Publicado: (2023)

Radiofluorination of an Anionic, Azide-Functionalized Teroligomer by Copper-Catalyzed Azide-Alkyne Cycloaddition
por: Wenzel, Barbara, et al.
Publicado: (2023)

Osmium Arene Germyl, Stannyl, Germanate, and Stannate Complexes as Anticancer Agents
por: Nabiyeva, Tomiris, et al.
Publicado: (2021)

Theoretical Study on the Mechanism of Cobalt-Catalyzed C–O Silylation and Stannylation
por: Cui, Cheng-Xing, et al.
Publicado: (2023)

Flumazenil-induced ballism.
por: Kim, Joong-Seok, et al.
Publicado: (2003)

Automated preparation of clinical grade [(68)Ga]Ga-DOTA-CP04, a cholecystokinin-2 receptor agonist, using iPHASE MultiSyn synthesis platform
por: Haskali, Mohammad B., et al.
Publicado: (2019)

Nickel-Catalyzed Decarbonylative Stannylation of Acyl Fluorides under Ligand-Free Conditions
por: Wang, Xiu, et al.
Publicado: (2019)

Investigation of the Selectivity of the Palladium-Catalyzed Aroylation and Arylation of Stannyl Glycals with Aroyl Chlorides
por: Shinozuka, Tsuyoshi
Publicado: (2021)

The adaptation of the desirability of outcome ranking for interventional clinical trials in epilepsy: A novel consumer‐led outcome measure
por: Vivash, Lucy, et al.
Publicado: (2023)

(18)F-fluorodeoxyglucose and (18)F-flumazenil positron emission tomography in patients with refractory epilepsy
por: Hodolic, Marina, et al.
Publicado: (2016)

Delayed Flumazenil Injection after Endoscopic Sedation Increases Patient Satisfaction Compared with Immediate Flumazenil Injection
por: Chung, Hyun Jung, et al.
Publicado: (2014)

(18)F-Labeled, PSMA-Targeted Radiotracers: Leveraging the Advantages of Radiofluorination for Prostate Cancer Molecular Imaging
por: Werner, Rudolf A., et al.
Publicado: (2020)

Automated Methods for Detecting and Quantitation of Enlarged Perivascular spaces on MRI
por: Moses, Jasmine, et al.
Publicado: (2022)

Paradoxical reaction to midazolam reversed with flumazenil
por: Cabrera, Luciano Santana, et al.
Publicado: (2010)

Effects of common anesthetic agents on [(18)F]flumazenil binding to the GABA(A) receptor
por: Palner, Mikael, et al.
Publicado: (2016)

Automated synthesis of [(18)F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models
por: Bouvet, Vincent, et al.
Publicado: (2016)

Automated Solid-Phase Radiofluorination Using Polymer-Supported Phosphazenes
por: Mathiessen, Bente, et al.
Publicado: (2013)

Continuous Infusion of Flumazenil in the Management of Benzodiazepines Detoxification
por: Benini, Anna, et al.
Publicado: (2021)

Remimazolam and low-dose flumazenil for awake craniotomy
por: Murata, Hiroaki, et al.
Publicado: (2022)

(η(6)-p-Cymene)bis(trichloridostannyl)(triethoxyphosphine-κP)ruthenium(II)
por: Shapovalov, Sergey S., et al.
Publicado: (2009)

(18)F-FDG-PET hypometabolism as a predictor of favourable outcome in epilepsy surgery: protocol for a systematic review and meta-analysis
por: Courtney, Merran R, et al.
Publicado: (2022)

Neurodegenerative pathways as targets for acquired epilepsy therapy development
por: Casillas‐Espinosa, Pablo M., et al.
Publicado: (2020)

Perivascular spaces as a potential biomarker of Alzheimer’s disease
por: Lynch, Miranda, et al.
Publicado: (2022)

A Radiofluorinated Divalent Cystine Knot Peptide for Tumor PET Imaging
por: Jiang, Lei, et al.
Publicado: (2014)

Development of Radiofluorinated Nicotinamide/Picolinamide Derivatives as Diagnostic Probes for the Detection of Melanoma
por: Lo, Yi-Hsuan, et al.
Publicado: (2021)

Sodium selenate as a therapeutic for tauopathies: A hypothesis paper
por: Dilcher, Roxane, et al.
Publicado: (2022)

A critical guide to the automated quantification of perivascular spaces in magnetic resonance imaging
por: Pham, William, et al.
Publicado: (2022)

Reversal of a Suspected Paradoxical Reaction to Zopiclone with Flumazenil
por: Jordahn, Zarah, et al.
Publicado: (2016)

Flumazenil reverses diazepam-induced neonatal apnoea and hypotonia
por: Cone, A. M., et al.
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_1mb54dc064shaav2l9jkj4d448