CRISPR/nCas9-Based Genome Editing on GM2 Gangliosidoses Fibroblasts via Non-Viral Vectors

The gangliosidoses GM2 are a group of pathologies mainly affecting the central nervous system due to the impaired GM2 ganglioside degradation inside the lysosome. Under physiological conditions, GM2 ganglioside is catabolized by the β-hexosaminidase A in a GM2 activator protein-dependent mechanism....

Descripción completa

Detalles Bibliográficos
Autores principales: Leal, Andrés Felipe, Cifuentes, Javier, Quezada, Valentina, Benincore-Flórez, Eliana, Cruz, Juan Carlos, Reyes, Luis Humberto, Espejo-Mojica, Angela Johana, Alméciga-Díaz, Carlos Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505638/
https://www.ncbi.nlm.nih.gov/pubmed/36142595
http://dx.doi.org/10.3390/ijms231810672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505638/
https://www.ncbi.nlm.nih.gov/pubmed/36142595
http://dx.doi.org/10.3390/ijms231810672

Ejemplares similares