Improving PARP inhibitor efficacy in high-grade serous ovarian carcinoma: A focus on the immune system

High-grade serous ovarian carcinoma (HGSOC) is a genomically unstable malignancy responsible for over 70% of all deaths due to ovarian cancer. With roughly 50% of all HGSOC harboring defects in the homologous recombination (HR) DNA repair pathway (e.g., BRCA1/2 mutations), the introduction of poly A...

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Detalles Bibliográficos
Autores principales: Bound, Nirashaa T., Vandenberg, Cassandra J., Kartikasari, Apriliana E. R., Plebanski, Magdalena, Scott, Clare L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505691/
https://www.ncbi.nlm.nih.gov/pubmed/36159999
http://dx.doi.org/10.3389/fgene.2022.886170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505691/
https://www.ncbi.nlm.nih.gov/pubmed/36159999
http://dx.doi.org/10.3389/fgene.2022.886170

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