Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778

Hepatitis B virus (HBV) capsid protein (Cp) is necessary for viral replication and the maintenance of viral persistence, having become an attractive target of anti-HBV drugs. To improve the water solubility of HBV capsid protein allosteric modulator (CpAM) NVR 3-778, a series of novel carboxylic aci...

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Detalles Bibliográficos
Autores principales: Ji, Xiangkai, Jiang, Xiangyi, Kobayashi, Chisa, Ren, Yujie, Hu, Lide, Gao, Zhen, Kang, Dongwei, Jia, Ruifang, Zhang, Xujie, Zhao, Shujie, Watashi, Koichi, Liu, Xinyong, Zhan, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505734/
https://www.ncbi.nlm.nih.gov/pubmed/36144715
http://dx.doi.org/10.3390/molecules27185987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505734/
https://www.ncbi.nlm.nih.gov/pubmed/36144715
http://dx.doi.org/10.3390/molecules27185987

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