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Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778

Hepatitis B virus (HBV) capsid protein (Cp) is necessary for viral replication and the maintenance of viral persistence, having become an attractive target of anti-HBV drugs. To improve the water solubility of HBV capsid protein allosteric modulator (CpAM) NVR 3-778, a series of novel carboxylic aci...

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Detalles Bibliográficos
Autores principales:	Ji, Xiangkai, Jiang, Xiangyi, Kobayashi, Chisa, Ren, Yujie, Hu, Lide, Gao, Zhen, Kang, Dongwei, Jia, Ruifang, Zhang, Xujie, Zhao, Shujie, Watashi, Koichi, Liu, Xinyong, Zhan, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505734/ https://www.ncbi.nlm.nih.gov/pubmed/36144715 http://dx.doi.org/10.3390/molecules27185987

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