Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity

APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and retrotransposons. APOBEC3G is a two-domain protein that restricts HIV. Although X-ray single-crystal structures of individual...

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Detalles Bibliográficos
Autores principales: Barzak, Fareeda M., Ryan, Timothy M., Mohammadzadeh, Nazanin, Harjes, Stefan, Kvach, Maksim V., Kurup, Harikrishnan M., Krause, Kurt L., Chelico, Linda, Filichev, Vyacheslav V., Harjes, Elena, Jameson, Geoffrey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505750/
https://www.ncbi.nlm.nih.gov/pubmed/36146779
http://dx.doi.org/10.3390/v14091974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505750/
https://www.ncbi.nlm.nih.gov/pubmed/36146779
http://dx.doi.org/10.3390/v14091974

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