Cargando…

Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity

APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and retrotransposons. APOBEC3G is a two-domain protein that restricts HIV. Although X-ray single-crystal structures of individual...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barzak, Fareeda M., Ryan, Timothy M., Mohammadzadeh, Nazanin, Harjes, Stefan, Kvach, Maksim V., Kurup, Harikrishnan M., Krause, Kurt L., Chelico, Linda, Filichev, Vyacheslav V., Harjes, Elena, Jameson, Geoffrey B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505750/ https://www.ncbi.nlm.nih.gov/pubmed/36146779 http://dx.doi.org/10.3390/v14091974

Ejemplares similares

Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A
por: Kurup, Harikrishnan M., et al.
Publicado: (2022)

Small-Angle X-ray Scattering Models of APOBEC3B Catalytic Domain in a Complex with a Single-Stranded DNA Inhibitor
por: Barzak, Fareeda M., et al.
Publicado: (2021)

Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A
por: Kurup, Harikrishnan M., et al.
Publicado: (2023)

Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA
por: Kvach, Maksim V., et al.
Publicado: (2019)

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues
por: Kvach, Maksim V., et al.
Publicado: (2018)

NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate
por: Harjes, Stefan, et al.
Publicado: (2017)

Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A
por: Harjes, Stefan, et al.
Publicado: (2023)

Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A
por: Harjes, Stefan, et al.
Publicado: (2023)

A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G
por: Shindo, Keisuke, et al.
Publicado: (2012)

Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance
por: Mohammadzadeh, Nazanin, et al.
Publicado: (2019)

Different Mutagenic Potential of HIV-1 Restriction Factors APOBEC3G and APOBEC3F Is Determined by Distinct Single-Stranded DNA Scanning Mechanisms
por: Ara, Anjuman, et al.
Publicado: (2014)

APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A
por: Wong, Lai, et al.
Publicado: (2020)

Special Issue “APOBECs and Virus Restriction”
por: Chelico, Linda
Publicado: (2021)

Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure
por: McDaniel, Yumeng Z, et al.
Publicado: (2020)

Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases
por: Wong, Lai, et al.
Publicado: (2022)

HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA
por: Morse, Michael, et al.
Publicado: (2019)

Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G
por: Yang, Hanjing, et al.
Publicado: (2020)

HIV-1 Viral Infectivity Factor (Vif) Alters Processive Single-stranded DNA Scanning of the Retroviral Restriction Factor APOBEC3G
por: Feng, Yuqing, et al.
Publicado: (2013)

Application of Cu(I)-catalyzed azide–alkyne cycloaddition for the design and synthesis of sequence specific probes targeting double-stranded DNA
por: Vasilyeva, Svetlana V, et al.
Publicado: (2016)

Stability of APOBEC3F in the Presence of the APOBEC3 Antagonist HIV-1 Vif Increases at the Expense of Co-Expressed APOBEC3H Haplotype I
por: Yousefi, Maria, et al.
Publicado: (2023)

Validation of macromolecular flexibility in solution by small-angle X-ray scattering (SAXS)
por: Hammel, Michal
Publicado: (2012)

Characterization of Crystal Microstructure Based on Small Angle X-ray Scattering (SAXS) Technique
por: Wang, Hongfan, et al.
Publicado: (2020)

Acoustical imaging
por: Ermert, Helmut, et al.
Publicado: (1992)

Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses
por: Gaba, Amit, et al.
Publicado: (2021)

Structural Characterization of Biomaterials by Means of Small Angle X-rays and Neutron Scattering (SAXS and SANS), and Light Scattering Experiments
por: Lombardo, Domenico, et al.
Publicado: (2020)

Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)
por: Hura, Greg L., et al.
Publicado: (2009)

Suppression of APOBEC3-mediated restriction of HIV-1 by Vif
por: Feng, Yuqing, et al.
Publicado: (2014)

Application of Small Angle X-ray Scattering (SAXS) for Differentiation between Normal and Cancerous Breast Tissue
por: Changizi, Vahid, et al.
Publicado: (2005)

Endothelial cell metabolism and implications for cancer therapy
por: Harjes, U, et al.
Publicado: (2012)

Picosecond pump–probe X-ray scattering at the Elettra SAXS beamline
por: Burian, Max, et al.
Publicado: (2020)

Deamination-independent restriction of LINE-1 retrotransposition by APOBEC3H
por: Feng, Yuqing, et al.
Publicado: (2017)

The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead
por: Granadillo Rodríguez, Milaid, et al.
Publicado: (2020)

Similar deamination activities but different phenotypic outcomes induced by APOBEC3 enzymes in breast epithelial cells
por: Granadillo Rodríguez, Milaid, et al.
Publicado: (2023)

ISPyB for BioSAXS, the gateway to user autonomy in solution scattering experiments
por: De Maria Antolinos, Alejandro, et al.
Publicado: (2015)

SAX2
por: Brownell, David
Publicado: (2002)

Retroviral Restriction Factor APOBEC3G Delays the Initiation of DNA Synthesis by HIV-1 Reverse Transcriptase
por: Adolph, Madison B., et al.
Publicado: (2013)

Amorphous nanoparticles in clays, soils and marine sediments analyzed with a small angle X-ray scattering (SAXS) method
por: Tsukimura, Katsuhiro, et al.
Publicado: (2021)

Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B
por: Adolph, Madison B, et al.
Publicado: (2017)

Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B
por: Adolph, Madison B, et al.
Publicado: (2018)

Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms
por: McDonnell, Mollie M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i26d4oc61epdh54ha7pu50t742