CCN1/Integrin α(5)β(1) Instigates Free Fatty Acid-Induced Hepatocyte Lipid Accumulation and Pyroptosis through NLRP3 Inflammasome Activation

Hyperlipidemia with high blood levels of free fatty acids (FFA) is the leading cause of non-alcoholic steatohepatitis. CCN1 is a secreted matricellular protein that drives various cellular functions, including proliferation, migration, and differentiation. However, its role in mediating FFA-induced...

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Detalles Bibliográficos
Autores principales: Yao, Qinyu, Liu, Jia, Cui, Qi, Jiang, Tingting, Xie, Xinya, Du, Xiong, Zhao, Ziwei, Lai, Baochang, Xiao, Lei, Wang, Nanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505842/
https://www.ncbi.nlm.nih.gov/pubmed/36145246
http://dx.doi.org/10.3390/nu14183871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505842/
https://www.ncbi.nlm.nih.gov/pubmed/36145246
http://dx.doi.org/10.3390/nu14183871

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