Biological Role of Pazopanib and Sunitinib Aldehyde Derivatives in Drug-Induced Liver Injury

Tyrosine kinase inhibitors pazopanib and sunitinib are both used to treat advanced renal cell carcinoma but expose patients to an increased risk of hepatotoxicity. We have previously identified two aldehyde derivatives for pazopanib and sunitinib (P-CHO and S-CHO, respectively) in liver microsomes....

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Detalles Bibliográficos
Autores principales: Maillard, Maud, Arellano, Cécile, Vachoux, Christelle, Chevreau, Christine, Cabaton, Nicolas J., Pont, Frédéric, Saint-Laurent, Nathalie, Lafont, Thierry, Chatelut, Etienne, Thomas, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505977/
https://www.ncbi.nlm.nih.gov/pubmed/36144257
http://dx.doi.org/10.3390/metabo12090852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505977/
https://www.ncbi.nlm.nih.gov/pubmed/36144257
http://dx.doi.org/10.3390/metabo12090852

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