Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce β Amyloid Plaque Formation and Improve Cognition Function

Presenilin-1 (PSEN1) is a crucial subunit within the γ-secretase complex and regulates β-amyloid (Aβ) production. Accumulated evidence indicates that n-butylidenephthalide (BP) acts effectively to reduce Aβ levels in neuronal cells that are derived from trisomy 21 (Ts21) induced pluripotent stem cel...

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Detalles Bibliográficos
Autores principales: Wuli, Wei, Lin, Shinn-Zong, Chen, Shee-Ping, Tannous, Bakhos A., Huang, Wen-Sheng, Woon, Peng Yeong, Wu, Yang-Chang, Yang, Hsueh-Hui, Chen, Yi-Cheng, Fleming, Renata Lopes, Rogers, Jack T., Cahill, Catherine M., Ho, Tsung-Jung, Chiou, Tzyy-Wen, Harn, Horng-Jyh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506169/
https://www.ncbi.nlm.nih.gov/pubmed/36142465
http://dx.doi.org/10.3390/ijms231810554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506169/
https://www.ncbi.nlm.nih.gov/pubmed/36142465
http://dx.doi.org/10.3390/ijms231810554

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