Cargando…

Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce β Amyloid Plaque Formation and Improve Cognition Function

Presenilin-1 (PSEN1) is a crucial subunit within the γ-secretase complex and regulates β-amyloid (Aβ) production. Accumulated evidence indicates that n-butylidenephthalide (BP) acts effectively to reduce Aβ levels in neuronal cells that are derived from trisomy 21 (Ts21) induced pluripotent stem cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wuli, Wei, Lin, Shinn-Zong, Chen, Shee-Ping, Tannous, Bakhos A., Huang, Wen-Sheng, Woon, Peng Yeong, Wu, Yang-Chang, Yang, Hsueh-Hui, Chen, Yi-Cheng, Fleming, Renata Lopes, Rogers, Jack T., Cahill, Catherine M., Ho, Tsung-Jung, Chiou, Tzyy-Wen, Harn, Horng-Jyh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506169/ https://www.ncbi.nlm.nih.gov/pubmed/36142465 http://dx.doi.org/10.3390/ijms231810554

Ejemplares similares

Chinese herbs and acupuncture to improve cognitive function in Alzheimer's disease
por: WuLi, Wei, et al.
Publicado: (2021)

Human-Induced Pluripotent Stem Cells and Herbal Small-Molecule Drugs for Treatment of Alzheimer’s Disease
por: Wuli, Wei, et al.
Publicado: (2020)

Advances in Patient-Specific Induced Pluripotent Stem Cells Shed Light on Drug Discovery for Amyotrophic Lateral Sclerosis
por: Lee, Jui-Hao, et al.
Publicado: (2018)

The Role of Biomaterials in Implantation for Central Nervous System Injury
por: Chen, Yu-Shuan, et al.
Publicado: (2018)

Effect of Cinnamomum osmophloeum Kanehira Leaf Aqueous Extract on Dermal Papilla Cell Proliferation and Hair Growth
por: Wen, Tung-Chou, et al.
Publicado: (2018)

Food Supplement 20070721-GX May Increase CD34(+) Stem Cells and Telomerase Activity
por: Lin, Po-Cheng, et al.
Publicado: (2012)

Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment
por: Liu, Ching-Ann, et al.
Publicado: (2018)

n-Butylidenephthalide Regulated Tumor Stem Cell Genes EZH2/AXL and Reduced Its Migration and Invasion in Glioblastoma
por: Yen, Ssu-Yin, et al.
Publicado: (2017)

n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway
por: Lee, Jui-Hao, et al.
Publicado: (2021)

Exosomes in clinical trial and their production in compliance with good manufacturing practice
por: Chen, Yu-Shuan, et al.
Publicado: (2019)

N-Butylidenephthalide Inhibits the Phenotypic Switch of VSMCs through Activation of AMPK and Prevents Stenosis in an Arteriovenous Fistula Rat Model
por: Yang, Hsin-Han, et al.
Publicado: (2020)

Pancreatic Adenocarcinoma Therapeutics Targeting RTK and TGF Beta Receptor
por: Yang, Hsin-Han, et al.
Publicado: (2021)

Isochaihulactone-induced DDIT3 causes ER stress-PERK independent apoptosis in glioblastoma multiforme cells
por: Tsai, Sheng-Feng, et al.
Publicado: (2016)

Induced Pluripotent Stem Cells: A Powerful Neurodegenerative Disease Modeling Tool for Mechanism Study and Drug Discovery
por: Chang, Chia-Yu, et al.
Publicado: (2018)

Robust Generation of Ready-to-Use Cryopreserved Motor Neurons from Human Pluripotent Stem Cells for Disease Modeling
por: Ting, Hsiao-Chien, et al.
Publicado: (2022)

Human Olfactory Ensheathing Cell Transplantation Improves Motor Function in a Mouse Model of Type 3 Spinocerebellar Ataxia
por: Hsieh, Jeanne, et al.
Publicado: (2017)

Amyloid-β(1–43) cerebrospinal fluid levels and the interpretation of APP, PSEN1 and PSEN2 mutations
por: Perrone, Federica, et al.
Publicado: (2020)

Non-Canonical Regulation of Type I Collagen through Promoter Binding of SOX2 and Its Contribution to Ameliorating Pulmonary Fibrosis by Butylidenephthalide
por: Chuang, Hong-Meng, et al.
Publicado: (2018)

Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening
por: Chang, Chia-Yu, et al.
Publicado: (2020)

Remote transplantation of human adipose-derived stem cells induces regression of cardiac hypertrophy by regulating the macrophage polarization in spontaneously hypertensive rats
por: Lee, Tsung-Ming, et al.
Publicado: (2019)

Host pre‐conditioning improves human adipose–derived stem cell transplantation in ageing rats after myocardial infarction: Role of NLRP3 inflammasome
por: Lee, Tsung‐Ming, et al.
Publicado: (2020)

Differentiation of Human Pluripotent Stem Cells Into Specific Neural Lineages
por: Chang, Chia-Yu, et al.
Publicado: (2021)

The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration
por: Chuang, Hong-Meng, et al.
Publicado: (2016)

Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress–mediated hippocampal damage after myocardial infarction
por: LEE, Tsung-Ming, et al.
Publicado: (2021)

Liposome Consolidated with Cyclodextrin Provides Prolonged Drug Retention Resulting in Increased Drug Bioavailability in Brain
por: Lin, En-Yi, et al.
Publicado: (2020)

Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells
por: Chiu, Sheng-Chun, et al.
Publicado: (2011)

Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress in Human Prostate Cancer Cells by n-butylidenephthalide
por: Chiu, Sheng-Chun, et al.
Publicado: (2012)

Integration of PEG 400 into a self-nanoemulsifying drug delivery system improves drug loading capacity and nasal mucosa permeability and prolongs the survival of rats with malignant brain tumors
por: Chen, Yu-Shuan, et al.
Publicado: (2019)

Interstitial Control-Released Polymer Carrying a Targeting Small-Molecule Drug Reduces PD-L1 and MGMT Expression in Recurrent High-Grade Gliomas with TMZ Resistance
por: Liu, Ching-Ann, et al.
Publicado: (2022)

Single nucleotide polymorphisms of the APC gene and colorectal cancer risk: a case-control study in Taiwan
por: Chen, Shee-Ping, et al.
Publicado: (2006)

Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2
por: Hsu, Simon, et al.
Publicado: (2020)

Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons
por: Ting, Hsiao-Chien, et al.
Publicado: (2021)

Mitochondrial Transplantation Moderately Ameliorates Retinal Degeneration in Royal College of Surgeons Rats
por: Wu, Shih-Fang, et al.
Publicado: (2022)

Identifying Therapeutic Targets for Spinocerebellar Ataxia Type 3/Machado–Joseph Disease through Integration of Pathological Biomarkers and Therapeutic Strategies
por: Chen, Yu-Shuan, et al.
Publicado: (2020)

PSEN as an Educational Tool in Norway
por: Westvik, Tormod Schumacher
Publicado: (2017)

APP, PSEN1, and PSEN2 Mutations in Asian Patients with Early-Onset Alzheimer Disease
por: Giau, Vo Van, et al.
Publicado: (2019)

The associations of APP , PSEN1 , and PSEN2 genes with Alzheimer's disease: A large case–control study in Chinese population
por: Xiao, Xuewen, et al.
Publicado: (2022)

From EST to structure models for functional inference of APP, BACE1, PSEN1, PSEN2 genes
por: Aathi, Muthusankar, et al.
Publicado: (2019)

APP, PSEN1, and PSEN2 Variants in Alzheimer’s Disease: Systematic Re-evaluation According to ACMG Guidelines
por: Xiao, Xuewen, et al.
Publicado: (2021)

Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy
por: Chang, Yu-Hsun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_omq755saiq8qo9kn4igmagv0d4