GB83, an Agonist of PAR2 with a Unique Mechanism of Action Distinct from Trypsin and PAR2-AP

Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor (GPCR) activated by proteolytic cleavage of its N-terminal domain. Once activated, PAR2 is rapidly desensitized and internalized by phosphorylation and β-arrestin recruitment. Due to its irreversible activation mechanism, some agon...

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Detalles Bibliográficos
Autores principales: Heo, Yunkyung, Yang, Eunhee, Lee, Yechan, Seo, Yohan, Ryu, Kunhi, Jeon, Hyejin, Namkung, Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506296/
https://www.ncbi.nlm.nih.gov/pubmed/36142527
http://dx.doi.org/10.3390/ijms231810631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506296/
https://www.ncbi.nlm.nih.gov/pubmed/36142527
http://dx.doi.org/10.3390/ijms231810631

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